The CREAK competence center in Dijon is coordinated by Professor Bernard Bonnotte of Internal Medicine and Clinical Immunology and Dr. Evelyne Collet of the Dermatology department of the Dijon University Hospital. They work closely with patients referred by their doctor for suspected angioedema. If necessary, they take samples for various dosages and genetic analyses if necessary, make diagnoses and start treatments by monitoring patients. Complex cases are discussed in local and national RCPs.